反应详情

A mixture of N-phenacylacetamide (0.70 g, 4 mmol), 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulphide (Lawesson's reagent) (0.80 g, 2 mmol) and toluene (10 ml) was heated for 1.5 h at reflux and then evaporated under reduced pressure. The residue was purified by chromatography (10 g silica, dichloromethane) to give 2-methyl-5-phenylthiazole as a yellowish solid (0.11 g, 16%) m.p. 72°-4° C.; δH (CDCl3) 7.85(1H, S, CH), 7.3-7.7(5H, m, C6H5), 2.7(3H, S, CH3).

1. temperaturewas heated for 1.5 h
2. temperatureat reflux
3. customevaporated under reduced pressure
4. customThe residue was purified by chromatography (10 g silica, dichloromethane)