Triethyl phosphite → Diethyl [(2-phenyl-1,3-oxazol-5-yl)methyl]phosphonate

Participants

Reaction Steps

5-Chloromethyl-2-phenyl oxazole (870 mgs, 4.50 mmol) and triethylphosphite (1.17 ml, 6.75 mmol) were heated at reflux for 3 h, cooled, the excess triethylphosphite removed under reduced pressure and the residue column chromatographed (0 to 5% MeOH/CH2Cl2, 10 g silica) to give the title compound (794 mgs, 2.69 mmol, 60%); δH (CDCl3) 1.30(6H,t,J 7 Hz,OCH2CH3), 3.30(2H,d,JP-H 22 Hz,CH2 -P) 4.10(4H,m,OCH2CH3), 7.00(1H,d,JP-H 3 Hz,CH-4), 7.40(3H,m,Ph), 8.00(2H,m,Ph).

Provenance & Evidence