反应详情

To an ice-cooled 10 ml of concentrated aqueous ammonia, was added dropwise 2.5 g of (-)-2-(pentafluorophenyl)-propanoyl chloride obtained in Example 5. After stirring for 30 minutes at room temperature, the reaction mixture was diluted with water, extracted with ethyl acetate and then dried over magnesium sulfate. The solvent was distilled off under reduced pressure, and the subsequent recrystallization from a hexane-ether mixed solvent gave 1.92 g of (-)-2-(pentafluorophenyl)propaneamide as colorless needles having the aforementioned physical properties.

1. extractionextracted with ethyl acetate
2. dry with materialdried over magnesium sulfate
3. distillationThe solvent was distilled off under reduced pressure
4. customthe subsequent recrystallization from a hexane-ether mixed solvent