4-Hydroxy-6-(4-trifluoromethylphenylthio)2-hexanone → 6-(4-Trifluoromethylphenylthio)-3-hexen-2-one

HRID 2249083Notes

Reaction equation

HRID 2249083 reaction equation
O[CH:2]([CH2:7][CH2:8][S:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=1)[CH2:3][C:4](=[O:6])[CH3:5]>C1(C)C=CC=CC=1>[F:18][C:16]([F:17])([F:19])[C:13]1[CH:14]=[CH:15][C:10]([S:9][CH2:8][CH2:7][CH:2]=[CH:3][C:4](=[O:6])[CH3:5])=[CH:11][CH:12]=1

Participants

3

Reactant 1

HCID 145344724-Hydroxy-6-(4-trifluoromethylphenylthio)2-hexanone

Product 1

HCID 572068326-(4-Trifluoromethylphenylthio)-3-hexen-2-one

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

0.5 Gram of 4-hydroxy-6-(4-trifluoromethylphenylthio)-2-hexanone was dissolved in 10 ml of toluene, and 0.26 g of Nafion® was added thereto. The resulting mixture was refluxed for 6 hours with stirring, allowed to cool and then treated in the same manner as in Production example 34. Thus, 6-(4-trifluoromethylphenylthio)-3-hexen-2-one was obtained (purity: 78.0%).

Workup

  1. temperatureThe resulting mixture was refluxed for 6 hours
  2. temperatureto cool
  3. additiontreated in the same manner as in Production example 34

Sources & evidence

ORD record
ord-d5323b3c04da4523b46c22b90996c116
Source dataset
uspto-grants-1991_08
Patent number
US05041679

Reaction notes

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