Boric Acid → 6-(4-Trifluoromethylphenylthio)-3-hexen-2-one

Participants

Reaction Steps

3.00 Grams of 4-hydroxy-6-(4-trifluoromethylphenylthio)-2-hexanone were dissolved in 50 ml of toluene, and 0.30 g of boric acid was added thereto. The resulting mixture was refluxed for 8 hours with stirring. The refluxed mixture, after allowed to cool, was washed with a saturated aqueous sodium hydrogencarbonate solution and then with a saturated aqueous sodium chloride solution. Then the mixture was dried over anhydrous magnesium sulfate. Removing the solvent from the mixture under reduced pressure gave 2.85 g of 6-(4-trifluoromethylphenylthio)-3-hexen-2-one (trans : cis =28.6 : 1)(purity: 97.7%). The yield was 98.7%.

Provenance & Evidence