Phosphoric Acid → 6-(4-Trifluoromethylphenylthio)-3-hexen-2-one

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Reaction Steps

3.00 Grams of 4-hydroxy-6-(4-trifluoromethylphenylthio)-2-hexanone were dissolved in 50 ml to toluene, and 0.50 g of 85% phosphoric acid, was added thereto. The resulting mixture was refluxed for 1 hour with stirring. After having been cooled, the mixture was washed with a saturated aqueous sodium hydrogencarbonate solution and then with a saturated aqueous sodium chloride solution. Then the mixture was dried over anhydrous magnesium sulfate. Removing the solvent from the mixture under reduced pressure gave 2.83 g of 6-(4-trifluoromethylphenylthio)-3-hexen-2-one (trans : cis=28 : 1) (purity: 84.2%). The yield was 84.7%.

Provenance & Evidence