2-Methoxyethanol → HCID 18646613, compound

HRID 2249127Notes

Reaction equation

HRID 2249127 reaction equation
Cl[C@H:2]1[C@H:14]2[C@H:10]([N:11]=[C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[O:13]2)[CH2:9][C:8]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]1=2.[Li].C[O:23]CCO>O>[C:15]1([C:12]2[O:13][C@H:14]3[CH:2]([OH:23])[C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][C:8]=4[CH2:9][C@H:10]3[N:11]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

5

Reactant 3

HCID 80192-MethoxyethanolHCID 3028194LithiumHCID 22843616HCID 22843616, compound

Product 1

HCID 18646613HCID 18646613, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

To a solution of (±)-(3aR,9R, 9aR)-9-chloro-3a, 4,9,9a-tetrahydro-2-phenyl-naphth[2,3-d]oxazole (360 mg) in 2-methoxyethanol (10 ml) was added a solution of lithium hydroxyde monohydrate (67 mg) in water (2 ml). The mixture was warmed at 90° C. for 1/2 hour and the title compound was precipitated by addition of water. Filtration, washing with water and drying in vacuo gave the title compound as a yellow solid (205 mg).

Workup

  1. customthe title compound was precipitated by addition of water
  2. filtrationFiltration
  3. washwashing with water
  4. customdrying in vacuo

Sources & evidence

ORD record
ord-3573b11624c343abae81e3e89c64216e
Source dataset
uspto-grants-1991_08
Patent number
US05041673

Reaction notes

Loading…