HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → HCID 13750678, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Methyl 4-carbamimidoylbenzoate--hydrogen chloride (1/1) | HCID 14226265 | — |
| Reactant | HCID 19891616 | HCID 19891616 | — |
| Reactant | HCID 86745012 | HCID 86745012 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 13750678 | HCID 13750678 | — |
Reaction Steps
A mixture of 40 g of 5-n-nonyl-2-(4-carbomethoxy- phenyl)-4,6-dichloropyrimidine (obtainable by condensing 4-carbomethoxybenzamidine hydrochloride with ethyl n-nonylmalonate and subsequently reacting the 4,6-dihydroxy compound with phosphorus oxychloride) and 40 ml of triethylamine is dissolved in 400 ml of methanol and, after addition of 20 g of 5 percent palladium carbon, hydrogenated under atmospheric pressure at 50° until the calculated amount of hydrogen has been taken up. Working up gives methyl p-(5-nonylpyrimidyl)-benzoate, m.p. 61.7°, c.p. 65°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05043093 |
| Source dataset | uspto-grants-1991_08 |
| ORD ID | ord-3e3f00698b4943828b2bf6d052c52ec5 |
| Source note | uspto-grants-1991_08 |