5-Amino-2,4,6-triiodoisophthaloyl dichloride → 2,4,6-triiodo-5-(((2-(1-methylethyl)-1,3-dioxan-5-yl)carbonyl)amino)-1,3-Benzenedicarbonyl dichloride

Participants

Reaction Steps

137 g of 5-amino-2,4,6-triiodoisophthaloyl chloride (0.23 mole) are dissolved in 460 ml of DMAC to which are added 110 g (0.57 mole) of 2-isopropyl-1,3-dioxane-5-carboxylic acid chloride. The reaction mixture is stirred under argon at ambient temperature for 4 days. The DMAC is removed in a vacuum. The oil obtained is extracted with 3 l of ethyl acetate and washed twice with 1 l of ice-cold water. The organic phase is dried and concentrated to dryness. The product is crystallized from 200 ml of CH2Cl2. After filtration, 110 g of solid are obtained:

Provenance & Evidence