Water → Ipriflavon alpha-cyclodextrin

HRID 2249149Notes

Reaction equation

HRID 2249149 reaction equation
[CH3:1][CH:2]([O:4][C:5]1[CH:6]=[CH:7][C:8]2[C:14](=[O:15])[C:13]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:12][O:11][C:9]=2[CH:10]=1)[CH3:3].[CH2:22]([OH:87])[C@H:23]1[O:28][C@@H:27]2[O:29][C@H:30]3[C@H:35]([OH:36])[C@@H:34]([OH:37])[C@@H:33]([O:38][C@H:39]4[C@H:44]([OH:45])[C@@H:43]([OH:46])[C@@H:42]([O:47][C@H:48]5[C@H:53]([OH:54])[C@@H:52]([OH:55])[C@@H:51]([O:56][C@H:57]6[C@H:62]([OH:63])[C@@H:61]([OH:64])[C@@H:60]([O:65][C@H:66]7[C@H:72]([OH:73])[C@@H:71]([OH:74])[C@@H:69]([O:70][C@H:24]1[C@H:25]([OH:86])[C@H:26]2[OH:85])[O:68][C@@H:67]7[CH2:75][OH:76])[O:59][C@@H:58]6[CH2:77][OH:78])[O:50][C@@H:49]5[CH2:79][OH:80])[O:41][C@@H:40]4[CH2:81][OH:82])[O:32][C@@H:31]3[CH2:83][OH:84].O>CC(C)=O>[CH3:3][CH:2]([O:4][C:5]1[CH:6]=[CH:7][C:8]2[C:14](=[O:15])[C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:12][O:11][C:9]=2[CH:10]=1)[CH3:1].[CH2:77]([OH:78])[C@H:58]1[O:59][C@@H:60]2[O:65][C@H:66]3[C@H:72]([OH:73])[C@@H:71]([OH:74])[C@@H:69]([O:70][C@H:24]4[C@H:25]([OH:86])[C@@H:26]([OH:85])[C@@H:27]([O:29][C@H:30]5[C@H:35]([OH:36])[C@@H:34]([OH:37])[C@@H:33]([O:38][C@H:39]6[C@H:44]([OH:45])[C@@H:43]([OH:46])[C@@H:42]([O:47][C@H:48]7[C@H:53]([OH:54])[C@@H:52]([OH:55])[C@@H:51]([O:56][C@H:57]1[C@H:62]([OH:63])[C@H:61]2[OH:64])[O:50][C@@H:49]7[CH2:79][OH:80])[O:41][C@@H:40]6[CH2:81][OH:82])[O:32][C@@H:31]5[CH2:83][OH:84])[O:28][C@@H:23]4[CH2:22][OH:87])[O:68][C@@H:67]3[CH2:75][OH:76]

Participants

5

Reactant 3

HCID 962WaterHCID 3747IpriflavoneHCID 444913Alpha-Cyclodextrin

Product 1

HCID 9833600Ipriflavon alpha-cyclodextrin

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

0.5 g (1.78 mmoles) of Ipriflavon were dissolved in 10 ml of acetone in pulg mortar and 4.0 g (3.70 mmoles) of α-cyclodextrin of 10% by weight moisture content and 2 ml of distilled water were added. The light suspension thus obtained was homogenized with a standing rubbing until the solvent was evaporated. Thereafter the product thus obtained was dried for 24 hours at 60° C. It contains 11.1% of active ingredient and also free α-cyclodextrin. Molar ratio of Ipriflavon to α-cyclodextrin=1:2.1.

Workup

  1. additionwere added
  2. customThe light suspension thus obtained
  3. customwas evaporated
  4. customThereafter the product thus obtained
  5. customwas dried for 24 hours at 60° C

Sources & evidence

ORD record
ord-c9fee403eb994ac29c856606675969ea
Source dataset
uspto-grants-1991_08
Patent number
US05043326

Reaction notes

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