Phosphonic acid, P-(chloromethyl)-, diethyl ester → Dibutyl diethyl methylenediphosphonate

HRID 2249150Notes

Reaction equation

HRID 2249150 reaction equation
[P:1]([O-:12])([O:7][CH2:8][CH2:9][CH2:10][CH3:11])[O:2][CH2:3][CH2:4][CH2:5][CH3:6].[Na+].Cl[CH2:15][P:16](=[O:23])([O:20][CH2:21][CH3:22])[O:17][CH2:18][CH3:19]>>[CH2:15]([P:1](=[O:12])([O:7][CH2:8][CH2:9][CH2:10][CH3:11])[O:2][CH2:3][CH2:4][CH2:5][CH3:6])[P:16](=[O:23])([O:20][CH2:21][CH3:22])[O:17][CH2:18][CH3:19]

Participants

3

Reactant 2

HCID 76633Phosphonic acid, P-(chloromethyl)-, diethyl esterHCID 23695934Sodium dibutyl phosphite

Product 1

HCID 13975061Dibutyl diethyl methylenediphosphonateYield 43%

Procedure

Dibutyl diethyl methylenediphosphonate was prepared in 43% yield by reacting sodium dibutyl phosphite with diethyl chloromethylphosphonate, bp=140° (0.05 mmHg), (Kugelrohr).

Sources & evidence

ORD record
ord-21c59db640e34593ba34e73a263c235b
Source dataset
uspto-grants-1991_08
Patent number
US05043330

Reaction notes

Loading…