HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 2,2-Dimethyl-chroman-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | alpha-Hydroxyacetophenone | HCID 68490 | — |
| Product | 2,2-Dimethyl-chroman-4-one | HCID 7454290 | — |
Reaction Steps
The reaction of 2-hydroxyacetophenone with acetone in the presence of pyrrolidine analogously to Synthesis 886, 1978 gives 2,2-dimethyl-4-chromanone of melting point 80°-85° C. 2,2-Dimethyl-4-hydroxy-chroman (oil) is obtained from 2,2-dimethyl-4-chromanone by reduction using sodium borohydride in ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05043344 |
| Source dataset | uspto-grants-1991_08 |
| ORD ID | ord-770cc114459c4f0090d402244fa44bc9 |
| Source note | uspto-grants-1991_08 |