HuagongsheHuagongshe Chemistry Print Report · For research reference only
o-(Trifluoromethyl)benzaldehyde → HCID 19825712, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | o-(Trifluoromethyl)benzaldehyde | HCID 123067 | — |
| Reactant | 6-Bromo-2,2-dimethyl-2H-chromene | HCID 11770533 | — |
| Reactant | HCID 178418306 | HCID 178418306 | — |
| Product | HCID 19825712 | HCID 19825712 | — |
Reaction Steps
6-Bromo-2,2-dimethyl-2H-chromene is metallated at -78° C. using 2 equivalents of tert.-butyllithium and subsequently reacted with 2-trifluoromethylbenzaldehyde to give 2,2-dimethyl-6-(2-trifluoromethyl-hydroxybenzyl)-2H-chromene which is produced as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05043344 |
| Source dataset | uspto-grants-1991_08 |
| ORD ID | ord-b4a7b1eff10248de8c7c1eedf1a17de9 |
| Source note | uspto-grants-1991_08 |