HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Cyclopropanemethanol | HCID 75644 | — |
| Reactant | 3-Chloro-4-(pyridin-3-yl)-1,2,5-thiadiazole | HCID 10488164 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)pyridine | HCID 19075239 | 69% |
Reaction Steps
To a solution of cyclopropylcarbinol (360 mg, 5 mmol) and sodiumhydride (110 mg, 5 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)-pyridine (490 mg, 2.5 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 3 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to yield 400 mg (69%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05043345 |
| Source dataset | uspto-grants-1991_08 |
| ORD ID | ord-9336349a7d8d40d686bf01978c07844b |
| Source note | uspto-grants-1991_08 |