HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2249236Generated: October 29, 2026
Sulfuric Acid → 5-Acetyl-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
https://huagongshe.com/reaction/2249236
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 5-Acetyl-2-hydroxy-6-methylnicotinonitrile | HCID 2765476 | — |
| Product | 5-Acetyl-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide | HCID 2764417 | — |
Reaction Steps
To 100 grams of concentrated sulfuric acid is added 10 g (0.056 mole) of 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile. The mixture is stirred at 60° C. for 5 hours, cooled and then poured on 1 kg ice. The resulting solid is collected, washed with water and recrystallized from ethanol to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05043449 |
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| Source dataset | uspto-grants-1991_08 |
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| ORD ID | ord-cf66096add84445c8d502a548c33823d |
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| Source note | uspto-grants-1991_08 |
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