Thionyl Chloride → 2,4,5-Trifluoro-3-methoxybenzoyl chloride

HRID 2249246Notes

Reaction equation

HRID 2249246 reaction equation
[CH3:1][O:2][C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6](O)=[O:7].S(Cl)([Cl:17])=O>>[CH3:1][O:2][C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6]([Cl:17])=[O:7]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 27339702,4,5-Trifluoro-3-methoxybenzoic acid

Product 1

HCID 27752812,4,5-Trifluoro-3-methoxybenzoyl chloride

Procedure

To 3-methoxy-2,4,5-trifluorobenzoic acid (9.4 g) was added thionyl chloride (50 ml), the mixture was refluxed for 3 hours and then concentrated. The residue was purified by distillation under reduced pressure to give 3-methoxy-2,4,5-trifluorobenzoyl chloride (8.86 g) as yellow oil, bp 108-112° C./20 mmHg.

Workup

  1. temperaturethe mixture was refluxed for 3 hours
  2. concentrationconcentrated
  3. distillationThe residue was purified by distillation under reduced pressure

Sources & evidence

ORD record
ord-a84f2ab565944ca8979025ea36832004
Source dataset
uspto-grants-1991_08
Patent number
US05043450

Reaction notes

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