Water → HCID 242937, compound

Participants

Reaction Steps

To a solution of 0.79 g (9.16 mmol) of piperazine in dry pyridine (20 ml) was added 5.15 g (20.15 mmol) of 4-bromobenzenesulfonyl chloride in an atmosphere of argon, and the mixture was allowed to react at 0° C. for 3 hours. To the solution was added water followed by extraction with ethyl acetate. The organic layer was washed with water and then concentrated under reduced pressure. The residue thus obtained was subjected to silica gel column chromatography for separation and purification. Elution with dichloromethane yielded 4.37 g (8.34 mmol) of N,N'-bis(4-bromobenzenesulfonyl)piperazine.

Provenance & Evidence