Ethyl 2-(pyridin-3-YL)thiazole-4-carboxylate → (2-Pyridin-3-yl-1,3-thiazol-4-yl)methanol

HRID 22493Notes

Reaction equation

HRID 22493 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[S:8][CH:9]=[C:10]([C:12](OCC)=[O:13])[N:11]=2)[CH:2]=1.N1(C2C=CC(C(OCC)=O)=CC=2)C2C=CC=CC=2N=C1>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[S:8][CH:9]=[C:10]([CH2:12][OH:13])[N:11]=2)[CH:2]=1

Participants

3

Reactant 2

HCID 2824169Ethyl 2-(pyridin-3-YL)thiazole-4-carboxylateHCID 60203616ethyl 4-(1H-benzimidazyl)benzoate

Product 1

HCID 4961264(2-Pyridin-3-yl-1,3-thiazol-4-yl)methanolYield 30%

Procedure

Utilising the procedure described in Example 23(d) employing ethyl 2-(3-pyridyl)-4-thiazolylcarboxylate (commercially available) in lieu of ethyl 4-(1H-benzimidazyl)benzoate gave (2-(3-pyridyl)-4-thiazolyl)methanol (30%) as a yellow crystalline solid.

Sources & evidence

ORD record
ord-5d8df4a25ffb4fa9ba98b20ab18a3f44
Source dataset
uspto-grants-1995_06
Patent number
US05428168

Reaction notes

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