Cefadroxil → Cefadroxil monohydrate

Participants

Reaction Steps

By employing the preferred reaction conditions described above, the present invention makes possible the production of primary grade cefadroxil in yields of up to about 90% (activity yields) and subsequent conversion of said cefadroxil or its dimethylformamide solvate to cefadroxil monohydrate in activity yields of up to about 83%. Overall yields of cefadroxil monohydrate from 7-ADCA range up to about 75% without taking into account the additional ~5% yield possible if a second crop of monohydrate is recovered from the crystallization mother liquor as described below in Example 5.

Provenance & Evidence