HCID 68808664, compound → HCID 68809865, compound

HRID 2249367Notes

Reaction equation

HRID 2249367 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([CH:10]([F:12])[F:11])[CH:5]=[CH:4][C:3]=1[N+:13]([O-])=O>C(O)C.[Pd]>[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([CH:10]([F:11])[F:12])[CH:5]=[CH:4][C:3]=1[NH2:13]

Participants

4

Reactant 1

HCID 68808664HCID 68808664, compound

Product 1

HCID 68809865HCID 68809865, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of crude 2-chloro-4-difluoromethyl-3-methoxy-1-nitrobenzene in ethanol (50 mL) containing 5% palladium on charcoal (250 mg) was hydrogenated (50 psi) for 5 hours. The solution was filtered and concentrated to give 2-chloro-4-difluoromethyl-3-methoxyaniline (1.3 g, 48 mmol): LC/MS (m/z=207).

Workup

  1. customfor 5 hours
  2. filtrationThe solution was filtered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-4180fe08d9dd45c3a4974919caf3417e
Source dataset
uspto-grants-2008_01
Patent number
US07314849B2

Reaction notes

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