反应详情

4-(4-tert-Butoxycarbonyl-1-piperazinyl)methyl-2-cyclopropylmethyl-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-one (121 mg, 0.26 mmol) was dissolved in trifluoroacetic acid (1.1 mL) under cooling with ice-water, and the solution was stirred for 15 minutes at the same temperature. Water (10 mL) was added to the reaction mixture, and the resultant mixture was made alkaline with potassium carbonate, followed by extraction with chloroform. The organic layer was washed with saturated brine (20 mL) and dried over sodium sulfate anhydrate, and the solvent was removed under reduced pressure, to thereby yield 83 mg (87.4%) of the title compound as a yellow oil.

1. extractionfollowed by extraction with chloroform
2. washThe organic layer was washed with saturated brine (20 mL)
3. dry with materialdried over sodium sulfate anhydrate
4. customthe solvent was removed under reduced pressure