2-cyclopropylmethyl-6-(2,3-dihydro-1-benzofuran-5-yl)-4-hydroxymethyl-2H-pyridazin-3-one → 2-(4-fluorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-4-hydroxymethyl-2H-pyridazin-3-one

HRID 2249414Notes

Reaction equation

HRID 2249414 reaction equation
C1(CN2C(=O)C(CO)=CC(C3C=CC4OCCC=4C=3)=N2)CC1.[C:23]([C:26]1[C:27](=[O:49])[N:28]([CH2:41][C:42]2[CH:47]=[CH:46][C:45]([F:48])=[CH:44][CH:43]=2)[N:29]=[C:30]([C:32]2[CH:33]=[CH:34][C:35]3[O:39][CH2:38][CH2:37][C:36]=3[CH:40]=2)[CH:31]=1)(O)=[O:24]>>[F:48][C:45]1[CH:44]=[CH:43][C:42]([CH2:41][N:28]2[C:27](=[O:49])[C:26]([CH2:23][OH:24])=[CH:31][C:30]([C:32]3[CH:33]=[CH:34][C:35]4[O:39][CH2:38][CH2:37][C:36]=4[CH:40]=3)=[N:29]2)=[CH:47][CH:46]=1

Participants

3

Reactant 2

HCID 230941232-cyclopropylmethyl-6-(2,3-dihydro-1-benzofuran-5-yl)-4-hydroxymethyl-2H-pyridazin-3-oneHCID 230941364-carboxy-2-(4-fluorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-one

Product 1

HCID 230941382-(4-fluorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-4-hydroxymethyl-2H-pyridazin-3-oneYield 43.4%

Procedure

The general procedure of Example 1 (4) was carried out by use of 4-carboxy-2-(4-fluorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-one, to thereby yield the title compound as a yellow oil (yield: 43.4%).

Sources & evidence

ORD record
ord-29919191ba9a4bae80a13b482dca071b
Source dataset
uspto-grants-2008_01
Patent number
US07314877B2

Reaction notes

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