4-carboxy-2-(4-chlorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-one → 2-(4-chlorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-4-hydroxymethyl-2H-pyridazin-3-one

HRID 2249418Notes

Reaction equation

HRID 2249418 reaction equation
FC1C=CC(CN2C(=O)C(CN3CCN(C)CC3)=CC(C3C=CC4OCCC=4C=3)=N2)=CC=1.[C:33]([C:36]1[C:37](=[O:59])[N:38]([CH2:51][C:52]2[CH:57]=[CH:56][C:55]([Cl:58])=[CH:54][CH:53]=2)[N:39]=[C:40]([C:42]2[CH:43]=[CH:44][C:45]3[O:49][CH2:48][CH2:47][C:46]=3[CH:50]=2)[CH:41]=1)(O)=[O:34]>>[Cl:58][C:55]1[CH:54]=[CH:53][C:52]([CH2:51][N:38]2[C:37](=[O:59])[C:36]([CH2:33][OH:34])=[CH:41][C:40]([C:42]3[CH:43]=[CH:44][C:45]4[O:49][CH2:48][CH2:47][C:46]=4[CH:50]=3)=[N:39]2)=[CH:57][CH:56]=1

Participants

3

Reactant 2

HCID 230941294-carboxy-2-(4-chlorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-oneHCID 230941322-(4-fluorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one

Product 1

HCID 230941252-(4-chlorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-4-hydroxymethyl-2H-pyridazin-3-oneYield 32.7%

Procedure

The general procedure of Example 1 (4) was repeated by use of 4-carboxy-2-(4-chlorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-one, to thereby yield the title compound as a pale yellow powder (yield: 32.7%).

Sources & evidence

ORD record
ord-d39d9756a45d42efab4a5eb0daf2bc72
Source dataset
uspto-grants-2008_01
Patent number
US07314877B2

Reaction notes

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