3-(2-Chlorophenyl)-1-propanol methanesulfonate → 4-carboxy-2-[3-(2-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-one

HRID 2249428Notes

Reaction equation

HRID 2249428 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:11]=[C:12]([C:17]([O:19]C)=[O:18])[C:13](=[O:16])[NH:14][N:15]=3)=[CH:9][C:4]=2[CH:3]=[CH:2]1.O1C2C=CC(C3C=C(C(OC)=O)C(=O)NN=3)=CC=2CC1.CS(O[CH2:46][CH2:47][CH2:48][C:49]1[CH:54]=[CH:53][CH:52]=[CH:51][C:50]=1[Cl:55])(=O)=O>>[C:17]([C:12]1[C:13](=[O:16])[N:14]([CH2:46][CH2:47][CH2:48][C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][C:50]=2[Cl:55])[N:15]=[C:10]([C:8]2[CH:7]=[CH:6][C:5]3[O:1][CH2:2][CH2:3][C:4]=3[CH:9]=2)[CH:11]=1)([OH:19])=[O:18]

Participants

4

Reactant 3

HCID 196884483-(2-Chlorophenyl)-1-propanol methanesulfonateHCID 23094117HCID 23094117, compoundHCID 23094139HCID 23094139, compound

Product 1

HCID 230941014-carboxy-2-[3-(2-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-oneYield 76.8%

Procedure

The general procedure of Example 1 (3) was carried out by use of 6-(2,3-dihydro-1-benzofuran-5-yl)-4-methoxycarbonyl-2H-pyridazin-3-one and 3-(2-chlorophenyl)-1-propanol methanesulfonate, to thereby yield the title compound as a yellow powder (yield: 76.8%).

Sources & evidence

ORD record
ord-2d975a1faa6c465e807cd0cf4cd81136
Source dataset
uspto-grants-2008_01
Patent number
US07314877B2

Reaction notes

Loading…