4-carboxy-2-[3-(2-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-one → 2-[3-(2-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-4-hydroxymethyl-2H-pyridazin-3-one

HRID 2249429Notes

Reaction equation

HRID 2249429 reaction equation
O1C2C=CC(C3C=C(C(O)=O)C(=O)N(CC4C=CC(F)=CC=4)N=3)=CC=2C=C1.[C:28]([C:31]1[C:32](=[O:56])[N:33]([CH2:46][CH2:47][CH2:48][C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][C:50]=2[Cl:55])[N:34]=[C:35]([C:37]2[CH:38]=[CH:39][C:40]3[O:44][CH2:43][CH2:42][C:41]=3[CH:45]=2)[CH:36]=1)(O)=[O:29]>>[Cl:55][C:50]1[CH:51]=[CH:52][CH:53]=[CH:54][C:49]=1[CH2:48][CH2:47][CH2:46][N:33]1[C:32](=[O:56])[C:31]([CH2:28][OH:29])=[CH:36][C:35]([C:37]2[CH:38]=[CH:39][C:40]3[O:44][CH2:43][CH2:42][C:41]=3[CH:45]=2)=[N:34]1

Participants

3

Reactant 2

HCID 230941014-carboxy-2-[3-(2-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-oneHCID 230941196-(1-benzofuran-5-yl)-4-carboxy-2-(4-fluorobenzyl)-2H-pyridazin-3-one

Product 1

HCID 230941082-[3-(2-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-4-hydroxymethyl-2H-pyridazin-3-oneYield 49.6%

Procedure

The general procedure of Example 1 (4) was carried out by use of 4-carboxy-2-[3-(2-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-one, to thereby yield the title compound as a yellow oil (yield: 49.6%).

Sources & evidence

ORD record
ord-267b1bc791cb42ddbc002e1c355f6ce0
Source dataset
uspto-grants-2008_01
Patent number
US07314877B2

Reaction notes

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