2-[3-(2-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-one → 2-[3-(4-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-4-hydroxymethyl-2H-pyridazin-3-one

HRID 2249431Notes

Reaction equation

HRID 2249431 reaction equation
ClC1C=CC=CC=1CCCN1C(=O)C(CN2CCN(C)CC2)=CC(C2C=CC3OCCC=3C=2)=N1.[C:35]([C:38]1[C:39](=[O:63])[N:40]([CH2:53][CH2:54][CH2:55][C:56]2[CH:61]=[CH:60][C:59]([Cl:62])=[CH:58][CH:57]=2)[N:41]=[C:42]([C:44]2[CH:45]=[CH:46][C:47]3[O:51][CH2:50][CH2:49][C:48]=3[CH:52]=2)[CH:43]=1)(O)=[O:36]>>[Cl:62][C:59]1[CH:60]=[CH:61][C:56]([CH2:55][CH2:54][CH2:53][N:40]2[C:39](=[O:63])[C:38]([CH2:35][OH:36])=[CH:43][C:42]([C:44]3[CH:45]=[CH:46][C:47]4[O:51][CH2:50][CH2:49][C:48]=4[CH:52]=3)=[N:41]2)=[CH:57][CH:58]=1

Participants

3

Reactant 2

HCID 115185912-[3-(2-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-4-(4-methyl-1-piperazinyl)methyl-2H-pyridazin-3-oneHCID 230941344-carboxy-2-[3-(4-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-one

Product 1

HCID 230941162-[3-(4-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-4-hydroxymethyl-2H-pyridazin-3-oneYield 53.3%

Procedure

The general procedure of Example 1 (4) was carried out by use of 4-carboxy-2-[3-(4-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-one, to thereby yield the title compound as a yellow oil (yield: 53.3%).

Sources & evidence

ORD record
ord-699aec4545f74fa29b10982d4f1388e2
Source dataset
uspto-grants-2008_01
Patent number
US07314877B2

Reaction notes

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