HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-fluoroaniline → 3-(3-Chloro-4-fluorophenyl)-5-methyl-hydantoin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-fluoroaniline | HCID 9708 | — |
| Reactant | Ethyl 2-isocyanatopropionate | HCID 550681 | — |
| Product | 3-(3-Chloro-4-fluorophenyl)-5-methyl-hydantoin | HCID 23330888 | — |
Reaction Steps
A mixture of 2.91 g (20 mmol) of 3-chloro-4-fluoroaniline and 3.01 g (21 mmol) of 2-isocyanato-propionic acid ethyl ester was maintained at 130°-140° C. for 91/2 hours. The resulting product was crystallized from chloroform/methanol to yield 3-(3-chloro-4-fluorophenyl)-5-methyl-hydantoin, m.p. 174°-175.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04234736 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-b7faf9d5b1ea471a9164a5baa35d0a30 |
| Source note | uspto-grants-1980_11 |