4-(3-Hydroxypropylamino)-3-nitropyridine → 3-Amino-4-(3-hydroxypropylamino)pyridine

Beteiligte Stoffe

Reaktionsschritte

4-(3-Hydroxypropylamino)-3-nitropyridine (4.12 g, 20.9 mmol) was dissolved in ethanol (130 ml) and Raney nickel (411 mg, 7.0 mmol) added. The stirred mixture was hydrogenated for 3 days. The catalyst was removed by filtration under argon and the solvent removed under reduced pressure to give 3-amino-4-(3-hydroxypropylamino)pyridine as a brown oil which was used directly in the next step.

Herkunft & Nachweise