Azidotrimethylsilane → HCID 178519389, compound

Participants

Reaction Conditions

Reaction Steps

(4-(2-(2,3-difluorophenyl)ethynyl)-1-BOC-pyrrol-2-yl)(pyrrolidin-1-yl)methanone (0.2 g, 0.5 mmol) was dissolved in trimethylsilylazide (3 mL) and heated at 150° C. for 18 hr. The solvent was evaporated and the crude product was purified by Biotage HPFC system (100% EtOAC) to afford title compound as a brown foam (0.019 g, 11%).; Mass Spec FIA MS 344; 1H NMR(CDCl3, 500 MHz) 10.05(s,1H), 7.06-7.25(m, 3H), 6.98(s,1H), 6.71(s,1H),3.55-3.60(m,4H), 1.79-1.95(m,4H).

Provenance & Evidence