Lithium borohydride → HCID 12272805, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (7-isopropyl-1H-indol-3-yl)-oxo-acetic acid ethyl ester (0.97 g. 3.7 mmol) in tetrahydrofuran was added 2.0 M solution of lithium borohydride in tetrahydrofuran. The mixture was heated at 90° C. for 5 hours. It was quenched with 5% HCl, followed by saturated sodium bicarbonate. It was extracted with ethyl acetate. The extracts were dried over magnesium sulfate and evaporated to dryness to provide a crude 2-(7-isopropyl -1H-indol-3-yl)-ethanol. ESI (+) MS m/e=204 (MH+), ESI (−) MS m/e=202 (MH−).

Provenance & Evidence