HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Cyanopyridine → HCID 178513339, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Cyanopyridine | HCID 79 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178513339 | HCID 178513339 | 89.2% |
Reaction Steps
3-Cyanopyridine (4.0 g) and hydroxylamine hydrochloride (3.2 g) were added to a solution of sodium (1.8 g) in MeOH (60 ml). The mixture was stirred 2.5 h at RT and refluxed 30 min. After cooling to RT, solids were filtered off. The solution was evaporated. White crystals (4.7 g) were obtained upon flash chromatography (125 g silica gel; CH2Cl2/MeOH 9:1) followed by a precipitation from heptan and ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07314884B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-2027ae332d774006a52f4c31f59160bc |
| Source note | uspto-grants-2008_01 |