反应详情

In 2 ml of ethanol is dissolved 200 mg of 2-[5-(2,4-diisobutoxybenzoyl)-2-isobutoxyphenyl]acetic acid. After adding 40 mg of 5% palladium-carbon, the mixture thus obtained is stirred at ambient temperature for one hour in a stream of hydrogen gas. The reaction mixture is filtered with Celite, and the solvent is distilled off under reduced pressure from the filtrate. The residue thus obtained is purified by silica gel column chromatography [eluent; n-hexane:ethyl acetate=4:1] to obtain 140 mg of 2-[5-(2,4-diisobutoxybenzyl)-2-isobutoxyphenyl]acetic acid as a colorless oily product.

1. customthe mixture thus obtained
2. filtrationThe reaction mixture is filtered with Celite
3. distillationthe solvent is distilled off under reduced pressure from the filtrate
4. customThe residue thus obtained
5. customis purified by silica gel column chromatography [eluent; n-hexane:ethyl acetate=4:1]