Hydrochloric Acid → HCID 68984650, compound

Participants

Reaction Steps

In 2 ml of methylene chloride is dissolved 0.15 g of 4-[3-(2-carboxyethyl)-4-isobutoxybenzoyl]-3-isobutoxybenzoic acid, to which is added 0.12 g of 1,1′-carbonyldiimidazole. After stirring the mixture at ambient temperature for one hour, 15 μl of methanol is added, and the mixture thus obtained is stirred at the same temperature as above for one hour. Ethyl acetate and water are added to the reaction mixture, pH is adjusted to 2 with 2 mol/L hydrochloric acid, and the organic layer is separated. The organic layer is washed with water and saturated aqueous solution of sodium chloride successively and dried over anhydrous magnesium sulfate, and the solvent is distilled off under reduced pressure to obtain 0.05 g of 3-isobutoxy-4-[4-isobutoxy-3-(3-methoxy-3-oxopropyl)benzoyl]benzoic acid as a white solid product.

Provenance & Evidence