Dimethylformamide → HCID 68987739, compound

Participants

Reaction Steps

In 40 ml of tetrahydrofuran is dissolved 4.00 g of 5-(2,4-diisobutoxybenzoyl)-2-isobutoxybenzoic acid, to which are added 0.95 ml of oxalyl chloride and 20 μl of N,N-dimethylformamide. The mixture thus obtained is stirred at ambient temperature for one hour. To the reaction mixture are added 3.03 g of glycine ethyl ester hydrochloride and 4.2 ml of triethylamine successively, and the mixture thus obtained is stirred for one hour under reflux with heating. The reaction mixture is cooled to ambient temperature, chloroform and water are added, and the organic layer is separated. The organic layer thus obtained is washed with water and saturated aqueous solution of sodium chloride successively and dried over anhydrous magnesium sulfate, and the solvent is distilled off under reduced pressure. The residue thus obtained is purified by silica gel column chromatography (eluent; hexane:ethyl acetate=2:1) to obtain 4.00 g of ethyl 2-{[5-(2,4-diisobutoxybenzoyl)-2-isobutoxybenzoyl]amino}acetate as a colorless oily product.

Provenance & Evidence