Hydrochloric Acid → HCID 17816559, compound

Participants

Reaction Steps

In 75 ml of N,N-dimethylformamide are suspended 7.5 g of 3-(3-ethoxy-3-oxopropyl)-4-hydroxybenzoic acid, 17.5 g of potassium carbonate and 7.4 ml of acetic anhydride. The mixture thus obtained is stirred at ambient temperature for 2 hours. The reaction mixture is added to a mixture of ethyl acetate and water, pH is adjusted to 2 with 6 mol/L hydrochloric acid, and the organic layer is separated. The organic layer is washed with water and saturated aqueous solution of sodium chloride successively and dried over anhydrous magnesium sulfate, and then the solvent is distilled off under reduced pressure. The residue is purified by silica gel column chromatography (eluent; hexane:ethyl acetate=5:1) to obtain 1.8 g of 4-(acetyloxy)-3-(3-ethoxy-3-oxopropyl)benzoic acid as a light brown-colored solid product.

Provenance & Evidence