2-Aminothiophenol → 2-(2-Aminophenyl)sulfanylbenzonitrile

HRID 2249705Notes

Reaction equation

HRID 2249705 reaction equation
C1C2[C:7]3[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=3[CH:9]=[N:10]SC=2C=CC=1.[NH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[SH:23].FC1C=CC=CC=1C#N>>[NH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23][C:7]1[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=1[C:9]#[N:10]

Participants

4

Reactant 3

HCID 87132-AminothiophenolHCID 678552-FluorobenzonitrileHCID 66579101Dibenzothiazepine

Product 1

HCID 3662332-(2-Aminophenyl)sulfanylbenzonitrile

Procedure

WO 92/19607 describes that a dibenzothiazepine derivative of the formula (5) can be prepared by the steps of reacting 2-aminothiophenol with 2-fluorobenzonitrile to give 2-(2-aminophenylthio)benzonitrile, hydrolyzing the resultant to give 2-(2-carboxyphenylthio)aniline, and finally cyclizing the aniline derivative.

Sources & evidence

ORD record
ord-3c959deaaff84d7aab2730db1e91b3e3
Source dataset
uspto-grants-2008_01
Patent number
US07314930B2

Reaction notes

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