3-Pentanamine → 4-Chloro-6-(1-ethyl-propylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde

HRID 2249719Notes

Reaction equation

HRID 2249719 reaction equation
Cl[C:2]1[C:7]([CH:8]=[O:9])=[C:6]([Cl:10])[N:5]=[C:4]([S:11][CH3:12])[N:3]=1.[CH3:13][CH2:14][CH:15]([NH2:18])[CH2:16][CH3:17]>>[Cl:10][C:6]1[C:7]([CH:8]=[O:9])=[C:2]([NH:18][CH:15]([CH2:16][CH3:17])[CH2:14][CH3:13])[N:3]=[C:4]([S:11][CH3:12])[N:5]=1

Participants

3

Reactant 2

HCID 120193-PentanamineHCID 46140044,6-Dichloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde

Product 1

HCID 98141174-Chloro-6-(1-ethyl-propylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde

Procedure

Prepared as described above in Example 2 starting from 4,6-dichloro-2-methylsulfanyl-pyrimidine-5-carbaldehyde and 3-pentylamine to give the title compound 4-chloro-6-(1-ethyl-propylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde. 1H-NMR: δ 0.92 (t, 6H, J=7.3 Hz), 1.50-1.74 (m, 4H), 2.52 (s, 3H), 4.22 (m, 1H), 9.21 (br s, 1H), 10.33 (s, 1H). LC MS (m/e)=274 (MH+).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-535be7c9adf5400c949f5e2e1646a3a6
Source dataset
uspto-grants-2008_01
Patent number
US07314881B2

Reaction notes

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