Isopropylamine → HCID 9834732, compound

HRID 2249720Notes

Reaction equation

HRID 2249720 reaction equation
Cl[C:2]1[C:7]([CH:8]=[O:9])=[C:6]([Cl:10])[N:5]=[C:4]([S:11][CH3:12])[N:3]=1.[CH:13]([NH2:16])([CH3:15])[CH3:14]>>[Cl:10][C:6]1[C:7]([CH:8]=[O:9])=[C:2]([NH:16][CH:13]([CH3:15])[CH3:14])[N:3]=[C:4]([S:11][CH3:12])[N:5]=1

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 46140044,6-Dichloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde

Product 1

HCID 9834732HCID 9834732, compound

Procedure

Prepared as described above in Example 2 starting from 4,6-dichloro-2-methylsulfanyl-pyrimidine-5-carbaldehyde and isopropylamine to give the title compound 4-chloro-6-isopropylamino-2-methylsulfanyl-pyrimidine-5-carbaldehyde. 1H-NMR: δ 1.31 (d, 6H, J=5.7 Hz), 2.60 (s, 3H), 4.47 (m, 1H), 9.16 (br s, 1H), 10.25 (s, 1H). LC MS (m/e)=246 (MH+).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-72960c9090cb46faaceeb72d906b68dd
Source dataset
uspto-grants-2008_01
Patent number
US07314881B2

Reaction notes

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