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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2249726생성일: 2026년 10월 25일

(4-Fluoro-2-methylphenyl)boronic acid → 4-(2,6-Difluoro-phenylamino)-6-(4-fluoro-2-methyl-phenyl)-2-methylsulfanyl-pyrimidine-5-carbaldehyde

https://huagongshe.com/reaction/2249726

반응식

참여 물질

역할이름HCID투입량
반응물(4-Fluoro-2-methylphenyl)boronic acidHCID 2734665—
반응물4-Chloro-6-((2,6-difluorophenyl)amino)-2-(methylthio)pyrimidine-5-carbaldehydeHCID 9944737—
생성물4-(2,6-Difluoro-phenylamino)-6-(4-fluoro-2-methyl-phenyl)-2-methylsulfanyl-pyrimidine-5-carbaldehydeHCID 10271633—

반응 단계

Prepared as described above in Example 11 starting from 4-chloro-6-(2,6-difluoro-phenylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde and 4-fluoro-2-methyl-phenylboronic acid to give the title compound 4-(2,6-difluoro-phenylamino)-6-(4-fluoro-2-methyl-phenyl)-2-methylsulfanyl-pyrimidine-5-carbaldehyde. 1H-NMR: δ 2.21 (s, 3H), 2.25 (s, 3H), 6.95 (m, 4H), 7.18 (m, 4H), 9.54 (s, 1H), 10.29 (br s, 1H). LC MS (m/e)=390 (MH+).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07314881B2
출처 데이터셋uspto-grants-2008_01
ORD IDord-98f451a057444163b75e57b677595a74
출처 메모uspto-grants-2008_01