2-Fluorophenylboronic acid → HCID 9856557, compound

HRID 2249731Notes

Reaction equation

HRID 2249731 reaction equation
[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[C:6](Cl)[N:5]=[C:4]([S:11][CH3:12])[N:3]=1.[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1B(O)O>>[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[C:6]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[F:13])[N:5]=[C:4]([S:11][CH3:12])[N:3]=1

Participants

3

Reactant 2

HCID 27343542-Fluorophenylboronic acidHCID 98557864-Amino-6-chloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde

Product 1

HCID 9856557HCID 9856557, compound

Procedure

Prepared as described above in Example 11 starting from 4-amino-6-chloro-2-methylsulfanyl-pyrimidine-5-carbaldehyde and 2-fluorophenylboronic acid to give the title compound 4-amino-6-(2-fluoro-phenyl)-2-methylsulfanyl-pyrimidine-5-carbaldehyde. 1H-NMR: δ 2.59 (s, 3H), 5.78 (br s, 1H), 7.11-7.32 (m, 2H), 7.42-7.58 (m, 2H), 8.65 (br s, 1H), 9.71 (s, 1H). LC MS (m/e)=264 (MH+).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-800a1f8e070d41ef8fdff49ed40f4566
Source dataset
uspto-grants-2008_01
Patent number
US07314881B2

Reaction notes

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