Serinol → HCID 10270606, compound

HRID 2249748Notes

Reaction equation

HRID 2249748 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]2[CH:21]=[CH:20][C:19](=[O:22])[N:18]([CH:23]([CH3:25])[CH3:24])[C:10]=2[N:11]=[C:12](S(C)(=O)=O)[N:13]=1.[NH2:26][CH:27]([CH2:30][OH:31])[CH2:28][OH:29]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]2[CH:21]=[CH:20][C:19](=[O:22])[N:18]([CH:23]([CH3:25])[CH3:24])[C:10]=2[N:11]=[C:12]([NH:26][CH:27]([CH2:30][OH:31])[CH2:28][OH:29])[N:13]=1

Participants

3

Reactant 2

HCID 68294SerinolHCID 10109217HCID 10109217, compound

Product 1

HCID 10270606HCID 10270606, compound

Procedure

The product of Example 52, and serinol were reacted by the procedure of Example 60 to afford the title compound 4-(2-fluoro-phenyl)-2-(2-hydroxy-1-hydroxymethyl-ethylamino)-8-isopropyl-8H-pyrido[2,3-d]pyrimidin-7-one. 1H-NMR: δ 1.54 (m, 6H), 3.80 (m, 4H), 4.11 (m, 1H), 5.75 (m, 1H), 6.19 (d, 1H, J=9.8), 6.38 (br s, 1H), 7.01-7.21 (m, 2H), 7.30-7.49 (m, 3H). LC MS (m/e)=373 (MH+).

Sources & evidence

ORD record
ord-91d84f03780e4f0a8537f5b20d8b14e5
Source dataset
uspto-grants-2008_01
Patent number
US07314881B2

Reaction notes

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