反应详情

A mixture of 2-guanidino-4-(4-aminobutyl)imidazole (0.15 g.) and methylisothiocyanate (0.1 g.) in ethanol (10 ml.) was stirred overnight and then evaporated to dryness. The residue was purified by chromatography on a silica gel column using chloroform/methanol/ammonia (s.g. 0.880) 80:20:0.3 v/v/v. The appropriate fractions on evaporation gave a gum which crystallized on triturating in petroleum ether (b.p. 40°-60° C.) to give 2-guanidino-4-[4-(3-methylthioureido)butyl]imidazole, m.p. 179°-184° C.

1. customevaporated to dryness
2. customThe residue was purified by chromatography on a silica gel column
3. customThe appropriate fractions on evaporation
4. customgave a gum which
5. customcrystallized
6. customon triturating in petroleum ether (b.p. 40°-60° C.)