Trifluoroacetic acid → HCID 59639565, compound

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Reaction Steps

The product of Example 130 (1 g, 1.9 mmol) was dissolved in CH2Cl2 (8 mL) and stirred under Ar in an ice bath. A chilled solution of 25% TFA in CH2Cl2 (40 mL) was added, and the mixture was stirred for 45 min at 0° C. The solvents were removed in vacuo, and the residue was partitioned between EtOAc and a saturated NaHCO3 solution. The organic phase was washed with H2O, satd aq NaCl, dried over anhyd Na2SO4, filtered and evaporated to give the crude product. Flash chromatography eluted with 0-10% MeOH/CH2Cl2 gave the title compound as a white-amorphous solid. mp 96-99°, LC MS m/z=427 (MH+) Retention time=1.52 min.

Provenance & Evidence