Methyl Isocyanate → 8-(2,6-Difluorophenyl)-4-(4-fluoro-2-methylphenyl)-2-[1-(2-aminoethyl)-3-methylureido]-8H-pyrido[2,3-d]pyrimidin-7-one

Participants

Role	Name	HCID	Charge
Reactant	Methyl Isocyanate	HCID 12228	—
Reactant	2-[(2-Aminoethyl)amino]-8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)pyrido[2,3-d]pyrimidin-7(8H)-one	HCID 59639577	—
Product	8-(2,6-Difluorophenyl)-4-(4-fluoro-2-methylphenyl)-2-[1-(2-aminoethyl)-3-methylureido]-8H-pyrido[2,3-d]pyrimidin-7-one	HCID 66893902	59.5%

Reaction Steps

The title compound from Example 157 (150 mg, 0.00035 mol) was treated with methylisocyanate (22 uL, 21.6 mg, 0.00035 mol) in the same manner as described in Example 158. Purification afforded 100.5 mg (59%) of the title compound as a light red solid (m.p. 124°-133°) LC MS (m/e)=452 (MH+). Rt=1.85 min.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07314881B2
Source dataset	uspto-grants-2008_01
ORD ID	ord-2c645df2af7e43729fdf4b7295077140
Source note	uspto-grants-2008_01