Ethanamine, 2,2,2-trifluoro- → HCID 59639602, compound

HRID 2249833Notes

Reaction equation

HRID 2249833 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=[C:12](S(C)(=O)=O)[N:13]=2)=[C:4]([CH3:30])[CH:3]=1.[F:31][C:32]([F:36])([F:35])[CH2:33][NH2:34]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=[C:12]([NH:34][CH2:33][C:32]([F:36])([F:35])[F:31])[N:13]=2)=[C:4]([CH3:30])[CH:3]=1

Participants

3

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 59639608HCID 59639608, compound

Product 1

HCID 59639602HCID 59639602, compoundYield 84%

Procedure

Following the general procedure outlined in Example 126, the product of Example 121 (150 mg, 0.35 mmol), 2,2,2-trifluoro-ethylamine (176 mg, 1.77 mmol) were reacted to give the crude material, which was purified as described in Example 198 to give the desired product 130 mg (84%). LC-MS: 443.0 (MH+, m/z), 2.27 (Rt, min).

Workup

  1. customto give the crude material, which
  2. customwas purified

Sources & evidence

ORD record
ord-c942f01b52a44f7d962402737e2f3f1d
Source dataset
uspto-grants-2008_01
Patent number
US07314881B2

Reaction notes

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