N-Nitro-S-methylisothiourea → HCID 178512642, compound

HRID 224985Notes

Reaction equation

HRID 224985 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH2:14])[N:9]=1)[C:2]([NH2:4])=[NH:3].CS[C:17](=[NH:22])[NH:18][N+:19]([O-:21])=[O:20]>C(O)C>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:17]([NH2:22])=[N:18][N+:19]([O-:21])=[O:20])[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

4

Reactant 2

HCID 135927615N-Nitro-S-methylisothioureaHCID 178512644HCID 178512644, compound

Product 1

HCID 178512642HCID 178512642, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-guanidino-4-(4-aminobutyl)thiazole (0.426 g.) in ethanol (10 ml.) was added 2-methyl-1-nitroisothiourea (0.270 g.). The mixture was heated under reflux for 4 hours, allowed to cool to room temperature, evaporated to dryness and the residue triturated with alcohol. The product was filtered off and dried to give 2-guanidino-4-[4-(2-nitroguanidino)butyl]thiazole, m.p. 180°-181° C.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 4 hours
  3. customevaporated to dryness
  4. customthe residue triturated with alcohol
  5. filtrationThe product was filtered off
  6. customdried

Sources & evidence

ORD record
ord-0c3a8d7cf5e74b648bdb43fb26e20ba0
Source dataset
uspto-grants-1980_11
Patent number
US04234735

Reaction notes

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