1-(3-Aminopropyl)-2-pyrrolidinone → 8-(2,6-Difluorophenyl)-4-(4-fluoro-2-methylphenyl)-2-[[3-(2-oxo-1-pyrrolidinyl)propyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one

Participants

Reaction Steps

Following the general procedure outlined in Example 225, the product of Example 48 (100 mg, 0.22 mmol) and N-(3′-aminopropyl)-2-pyrrolidinone (96 mg, 0.67 mmol) were reacted to give the crude material. Purification by flash chromatography eluting with EtOAc/hexane/triethylamine (70/30/2, v/v/v), followed by recrystallization from ethanol and hexane, gave the desired product 95 mg (85%). LC-MS: 508.2 (MH+, m/z), 2.02 (Rt, min).

Provenance & Evidence