Tert-butyl 5-nitro-1H-indole-1-carboxylate → tert-Butyl 5-amino-2,3-dihydro-1H-indole-1-carboxylate

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Reaction Steps

A solution of 5-nitro-indole-1-carboxylic acid tert-butyl ester (0.50 g) and catalytic amount of Pd(OH)2 in a mixture of MeOH-EtOAc was stirred at room temperature under hydrogen for 1 h. The reaction mixture was filtered through celite and the filtrate was concentrated to provide 5-amino-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester (0.44 g, 98%).

Provenance & Evidence