Serinol → HCID 10221610, compound

HRID 2250016Notes

Reaction equation

HRID 2250016 reaction equation
[CH:1]1([CH2:4][N:5]2[C:10]3[N:11]=[C:12](S(C)(=O)=O)[N:13]=[C:14]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=4[F:21])[C:9]=3[CH:8]=[CH:7][C:6]2=[O:26])[CH2:3][CH2:2]1.[NH2:27][CH:28]([CH2:31][OH:32])[CH2:29][OH:30]>>[CH:1]1([CH2:4][N:5]2[C:10]3[N:11]=[C:12]([NH:27][CH:28]([CH2:31][OH:32])[CH2:29][OH:30])[N:13]=[C:14]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=4[F:21])[C:9]=3[CH:8]=[CH:7][C:6]2=[O:26])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 68294SerinolHCID 10133918HCID 10133918, compound

Product 1

HCID 10221610HCID 10221610, compound

Procedure

The product of Example 50, and serinol were reacted by the procedure of Example 60 to afford the title compound 8-cyclopropylmethyl-4-(2-fluoro-phenyl)-2-(2-hydroxy-1-hydroxymethyl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one. 1H-NMR: δ 0.40 (m, 4H), 1.25 (m, 1H), 3.89 (m, 4H), 4.13 (m, 3H), 5.75 (m, 1H), 6.30 (d, 1H, J=9.8 Hz), 6.59 (br s, 1H), 7.08-7.48 (m, 5H). LC MS (m/e)=385 (MH+).

Sources & evidence

ORD record
ord-111117f8a43341638c1ba5b98e213993
Source dataset
uspto-grants-2008_01
Patent number
US07314934B2

Reaction notes

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