Sodium Methoxide → HCID 59639556, compound

HRID 2250041Notes

Reaction equation

CO[C:3](=[O:30])/[CH:4]=[CH:5]/[C:6]1[C:7]([NH:21][C:22]2[C:27]([F:28])=[CH:26][CH:25]=[CH:24][C:23]=2[F:29])=[N:8][C:9](SC)=[N:10][C:11]=1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[F:18].[CH3:31][O-:32].[Na+]>>[F:28][C:27]1[CH:26]=[CH:25][CH:24]=[C:23]([F:29])[C:22]=1[N:21]1[C:7]2[N:8]=[C:9]([O:32][CH3:31])[N:10]=[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[F:18])[C:6]=2[CH:5]=[CH:4][C:3]1=[O:30]

Participants

Reactant 2

HCID 10942334Sodium Methoxide

HCID 66894140HCID 66894140, compound

Product 1

HCID 59639556HCID 59639556, compound

Procedure

Prepared as described above in Example 98 starting from (E)-3-[4-(2,6-difluoro-phenyl amino)-6-(2-fluoro-phenyl)-2-methylsulfanyl-pyrimidin-5-yl]-acrylic acid methyl ester and sodium methoxide to afford the title compound 8-(2,6-difluoro-phenyl)-4-(2-fluoro-phenyl)-2-methoxy-8H-pyrido[2,3-d]pyrimidin-7-one. 1H-NMR (CDCl3) δ 3.82 (s, 3H), 6.56 (d, 1H, J=9.6 Hz), 7.08 (m, 2H), 7.26-7.59 (m, 6H). LC MS (m/e)=384 (MH+). Rt=2.22 min.

Workup

customPrepared

Sources & evidence

ORD record: ord-b06aa346d66d4943acc77ec9e00902b6
Source dataset: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07314934B2

Reaction notes

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